Shahmohammadi Sayeh
New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives.
[Thesis]
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Abstract in foreign language
The present Ph.D. work has been planned to accomplish two major goals. In view of the significance of fluorine-substituted compounds, the first aim was to synthesize a selection of (±)-β-amino carboxylic ester hydrochloride salts 3a–e, then to generate an appropriate lipase-catalyzed method for their resolution through hydrolysis, furnishing enantiopure new β-fluorophenyl-substituted β-amino acids (S)-5a–e and unreacted β-amino esters (R)-4a–e. The second objective of my work was a comparative investigation of different green strategies and then to build an environmentally benign CALB-catalyzed hydrolysis of cis carbocyclic amino esters 6–9.
Item Type: | Thesis (Doktori értekezés) |
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Creators: | Shahmohammadi Sayeh |
Title of the thesis in foreign language: | New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives |
Subjects: | 01. Natural sciences > 01.04. Chemical sciences 01. Natural sciences > 01.04. Chemical sciences > 01.04.01. Organic chemistry 03. Medical and health sciences |
Divisions: | Doctoral School of Pharmaceutical Sciences |
Tudományterület / tudományág: | Medicine > Pharmacy |
Nyelv: | English |
Date: | 2022. May 27. |
Item ID: | 11328 |
Date Deposited: | 2022. May. 30. 08:15 |
Last Modified: | 2022. May. 30. 08:15 |
URI: | https://doktori.bibl.u-szeged.hu/id/eprint/11328 |
Defence/Citable status: | Not Defended. (Do not cite until it has not assigned DOI number!) |
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