New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives

Shahmohammadi Sayeh
New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives.
[Thesis]

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Abstract in foreign language

The present Ph.D. work has been planned to accomplish two major goals. In view of the significance of fluorine-substituted compounds, the first aim was to synthesize a selection of (±)-β-amino carboxylic ester hydrochloride salts 3a–e, then to generate an appropriate lipase-catalyzed method for their resolution through hydrolysis, furnishing enantiopure new β-fluorophenyl-substituted β-amino acids (S)-5a–e and unreacted β-amino esters (R)-4a–e. The second objective of my work was a comparative investigation of different green strategies and then to build an environmentally benign CALB-catalyzed hydrolysis of cis carbocyclic amino esters 6–9.

Item Type: Thesis (Doktori értekezés)
Creators: Shahmohammadi Sayeh
Title of the thesis in foreign language: New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives
Subjects: 01. Natural sciences > 01.04. Chemical sciences
01. Natural sciences > 01.04. Chemical sciences > 01.04.01. Organic chemistry
03. Medical and health sciences
Divisions: Doctoral School of Pharmaceutical Sciences
Tudományterület / tudományág: Medicine > Pharmacy
Nyelv: English
Date: 2022. May 27.
Item ID: 11328
Date Deposited: 2022. May. 30. 08:15
Last Modified: 2022. May. 30. 08:15
URI: https://doktori.bibl.u-szeged.hu/id/eprint/11328
Defence/Citable status: Not Defended. (Do not cite until it has not assigned DOI number!)

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