New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives

Shahmohammadi Sayeh
New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives.
Doctoral thesis (PhD), University of Szeged.
(2022)

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Abstract in foreign language

The present Ph.D. work has been planned to accomplish two major goals. In view of the significance of fluorine-substituted compounds, the first aim was to synthesize a selection of (±)-β-amino carboxylic ester hydrochloride salts 3a–e, then to generate an appropriate lipase-catalyzed method for their resolution through hydrolysis, furnishing enantiopure new β-fluorophenyl-substituted β-amino acids (S)-5a–e and unreacted β-amino esters (R)-4a–e. The second objective of my work was a comparative investigation of different green strategies and then to build an environmentally benign CALB-catalyzed hydrolysis of cis carbocyclic amino esters 6–9.

Item Type:	Thesis (Doctoral thesis (PhD))
Creators:	Shahmohammadi Sayeh
Supervisor(s):	Supervisor Position, academic title, institution MTMT author ID Forró Enikő MTA doktora, Gyógyszerkémiai Intézet SZTE / GYTK 10002835 Fülöp Ferenc professzor, Gyógyszerkémiai Intézet SZTE / GYTK 1381350
Subjects:	01. Natural sciences > 01.04. Chemical sciences 01. Natural sciences > 01.04. Chemical sciences > 01.04.01. Organic chemistry 03. Medical and health sciences
Divisions:	Doctoral School of Pharmaceutical Sciences
Discipline:	Medicine > Pharmacy
Language:	English
Date:	2022. August 24.
Item ID:	11328
MTMT identifier of the thesis:	34118001
doi:	https://doi.org/10.14232/phd.11328
Date Deposited:	2022. May. 30. 08:15
Last Modified:	2023. Aug. 29. 14:09
Depository no.:	B 7158
URI:	https://doktori.bibl.u-szeged.hu/id/eprint/11328
Defence/Citable status:	Defended.

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