Pharmaceutical development of co-crystals

Venczel, Márta
Pharmaceutical development of co-crystals.
[Thesis] (Unpublished)

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Abstract in foreign language

Co-crystals are solids that are crystalline materials composed of two or more molecules in the same crystal lattice. Formation of co-crystals can solve several pharmaceutical issues raised during preformulation and formulation development e.g. by solubility, dissolution, bioavailability, chemical stability, decreasing hygroscopicity modulation. Formation of co-crystals could be a new path to improve physico-chemical and biopharmaceutical properties of medicines. One of the most difficult pharmaceutical formulation tasks is to improve the absorption of a weak base with poor and pH-dependent solubility properties; however, some combined chemical and formulation approaches give the possibility to reach this goal. Usually applied chemical tools are the salt and/or co-crystal formation, while the pharmaceutical approaches are micronization, nanonization, and elaboration of lipidic and amorphous formulations. However, to reach the targeted pharmacokinetic/pharmacodynamic (PK/PD) profiles, synergies of different chemical and pharmaceutical tools are needed.

Item Type: Thesis (PhD)
Creators: Venczel, Márta
Hungarian title label: Ko-kristályok gyógyszerészeti fejlesztése
Divisions: Doctoral School of Pharmaceutical Sciences
Discipline label: Medicine > Pharmacy
Defence date label: 2012. July 02.
Item ID: 1454
MTMT id: 2241557
Date Deposited: 2012. Apr . 24. 09:09
Last Modified: 2019. Nov . 05. 13:11
Depository no.: B 5404
Defence/Citable status: Defended.

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