Pharmaceutical development of co-crystals

Venczel Márta
Pharmaceutical development of co-crystals.
Doctoral thesis (PhD), University of Szeged.
(2012) (Unpublished)

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Abstract in foreign language

Co-crystals are solids that are crystalline materials composed of two or more molecules in the same crystal lattice. Formation of co-crystals can solve several pharmaceutical issues raised during preformulation and formulation development e.g. by solubility, dissolution, bioavailability, chemical stability, decreasing hygroscopicity modulation. Formation of co-crystals could be a new path to improve physico-chemical and biopharmaceutical properties of medicines. One of the most difficult pharmaceutical formulation tasks is to improve the absorption of a weak base with poor and pH-dependent solubility properties; however, some combined chemical and formulation approaches give the possibility to reach this goal. Usually applied chemical tools are the salt and/or co-crystal formation, while the pharmaceutical approaches are micronization, nanonization, and elaboration of lipidic and amorphous formulations. However, to reach the targeted pharmacokinetic/pharmacodynamic (PK/PD) profiles, synergies of different chemical and pharmaceutical tools are needed.

Item Type: Thesis (Doctoral thesis (PhD))
Creators: Venczel Márta
Hungarian title: Ko-kristályok gyógyszerészeti fejlesztése
Position, academic title, institution
MTMT author ID
Pintye-Hódi Klára
Habil., PhD, DSc, SZTE GYTK Gyógyszertechnológiai Intézet
Subjects: 03. Medical and health sciences > 03.01. Basic medicine > 03.01.06. Pharmacology and pharmacy
Divisions: Doctoral School of Pharmaceutical Sciences
Discipline: Medicine > Pharmacy
Language: English
Date: 2012. July 02.
Item ID: 1454
MTMT identifier of the thesis: 2241557
Date Deposited: 2012. Apr. 24. 09:09
Last Modified: 2019. Nov. 05. 13:11
Depository no.: B 5404
Defence/Citable status: Defended.

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