Erectile dysfunction and the biochemical/molecular/ regulation of human penile arteries

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1.Flow mediated vasodilation as a new, non-invasive diagnostic procedure in the examination of vascular type erectile dysfunction. 2.CNP has a strong vasodilatation effect on human resistance vessels in the presence of NO synthase and cyclooxygenase enzyme inhibitors 3.That relaxation demonstrates a similar characteristics as an EDHF released by Ach 4.CNP has a smooth muscle cells hyperpolarization effect similar to Ach 5.Our examinations prove CNP is an EDHF in human penile resistance vessels which plays an essential role in the reduction of vessel tone supporting erection. 6.CNP or its similar compounds may be successful in the treatment of erectile dysfunction. 7.NO and EDHF take part in the endothelium dependence relaxation human penile intracavernosus arteries. 8.BKC channels play an essential role in the establishment of the effect enduced by both of NO and EDHF 9.During our examination the opening compounds of BKC channels are assumed to be effective in the treatment of disregulation of penile arteries. 10.The Hungarian implementation of female to male sexual reassignment operation Development of the surgical technique in our Department of Urology has lead to better functional and esthetical results. These modifications are the following -The turned down u-shape perineal incision was exchanged by median sagittal incision-The expert preparation of neurovascular bundle -Reaching clitoral orgasm a greater part of the glans is used at the creation of clitoris, one part of it is deepithelialized and it is sunk under the skin. The fixing sutures of the neo clitoris is placed into foreskin to avoid circular damage.

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